Dr. Stefan Constantinescu

Sept 2005 - Jak/Stat and Cytokine Receptor Research at the Ludwig Institute for Cancer Research (Brussels, Belgium)

The Signal Transduction Group headed by Dr. Stefan Constantinescu, has been studying the mechanisms by which cytokine receptors, such as the receptors for erythropoietin (EpoR) and thrombopoietin (Tpo), respectively, which interact with and activate Janus tyrosine kinases (JAKs) that in turn activate signal transducers and activators of transcription (STAT) proteins. The group's work on the TpoR traffic triggered an interest in the cause of Polycythemia Vera (PV) and two other related diseases that progress to acute leukemia.

Work-team at the institute
TOP Lft to Rt
: postdoc alumni Virginie Moucadel, PhD student Yohan Royer, Visiting Scientist Marcel Costuleanu (Univ. of Medicine Iasi, Romania), Stefan Constantinescu, PhD student Judith Staerk, technician Yan Yin, postdoc alumni Katharina Kubatzky (presently a faculty at University of Freiburg
BTM Left to Rt: postdoc Carmen Diaconu (permanent staff at the Stefan S. Nicolau Institute of Virology, Bucharest, Romania), PhD student Alexandra Dusa, administrative assistant Julie Klein and postdoc Michael Girardot

Photo © LICR

Stefan N. Constantinescu, MD, PhD
Group Leader, Signal Transduction Unit
Ludwig Institute for Cancer Research
Member, Christian de Duve Institute of Cellular Pathology, UCL
Avenue Hippocrate 74, UCL 75-4
Brussels B-1200, Belgium
Tel: 322-764-75-40
Fax: 322-764-65-66
E.Mail: stefan.constantinescu@bru.licr.org